【摘 要】
：
目的 制备一种适配体门控的介孔二氧化硅纳米粒，观察其体外靶向效果及超声触发药物释放效果.方法 采用碳二亚胺法连接适配体来制备适配体门控的靶向纳米粒.并检测其理化性质及超声显影.装载荧光素于纳米粒内，体外运用低强度聚焦超声(LIFU)仪辐照后，观察其释放效果.结果 所制备的样品为适配体门控的介孔二氧化硅纳米粒，球形，平均粒径为(513.4± 0.557)nm；LIFU辐照后可观察到明显的荧光素释放增
【机 构】
：
400010重庆市,超声分子影像重庆市重点实验室,重庆医科大学超声影像学研究所
【出 处】
：
第一届全国暨第二届国际超声分子影像学术会议
论文部分内容阅读
目的 制备一种适配体门控的介孔二氧化硅纳米粒，观察其体外靶向效果及超声触发药物释放效果.方法 采用碳二亚胺法连接适配体来制备适配体门控的靶向纳米粒.并检测其理化性质及超声显影.装载荧光素于纳米粒内，体外运用低强度聚焦超声(LIFU)仪辐照后，观察其释放效果.结果 所制备的样品为适配体门控的介孔二氧化硅纳米粒，球形，平均粒径为(513.4± 0.557)nm；LIFU辐照后可观察到明显的荧光素释放增强.结论 成功制备适配体门控的介孔二氧化硅纳米粒，体外经LIFU仪器辐照后明显增强药物释放效果.
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