【摘 要】
：
Age is a major risk factor for morbidity and mortality for many infections caused by various pathogens.Many infectious diseases,such as influenza,tuberculos
【机 构】
：
KeyLaboratoryofAnimalModelsandHumanDiseaseMechanismsofChineseAcademyofSciences&YunnanProvince,Kunmin
论文部分内容阅读
Age is a major risk factor for morbidity and mortality for many infections caused by various pathogens.Many infectious diseases,such as influenza,tuberculosis and AIDS,often spread with greater frequency or severity in aged population.This way may be attributed to diminishing immune protection with age,which is commonly referred to as immunosenescence.Most studies over the past decades describing age-related modifications in immune system were based on rodent models.However,as a long-lived species of non-human primates and sharing greater genetic and physiological similarities with humans than rodent models,Rhesus macaques(RM,Macaca mulatta)can offer more distinct advantages to research immunosenescence.Here,we investigated phenotypic features of T and B-cell aging in peripheral blood from Chinese rhesus macaques(ChRM),included(1)a decrease of CD4/CD8 ratio;(2)a loss of na?ve T cells accompanied with elevated proliferation and expansion of effector memory subset;(3)a reduction in B cell numbers and a shift from na?ve B cells towards memory phenotype; and(4)increased levels of PD-1 expression in T cells and CD95 expression in B cells.Moreover,an accelerated decline in CD4+ T cells and na?ve T cells was found in male macaques,giving them a more severe immune risk profile.These data indicated Chinese rhesus macaques share a significant homology with humans in phenotypic aging of adaptive immunity,and may be an appropriate animal model for human aging research.
其他文献
本文利用超高交联树脂HD-01从实际发酵液中回收DLA.研究了乳酸以及其他组分和多组分(葡萄糖,乳酸,乙酸)的吸附热力学,和竞争性Langmuir等温线模型很好的拟和单组分和多组分试
The nitrate-dependent anaerobic ferrous oxidizing(NAFO)is a newly discovered autotrophic bioprocess,which was valuable to develop autotrophic denitrifying t
Epigenetic information is stored in the form of modified bases in the genome.The positions and the kind of the base modifications determines the identity of the
The Xenopus egg is a huge cell,1.2 mm in diameter.Since it takes hours for a proteinto diffuse over those distances,one might expect that global processes like
Saccharomyces cerevisiae (budding yeast) represents an ideal model system forstudying cell polarization and gradient sensing.Here we combine mathematicalmodelin
Employing small molecules or chemical reagents to modulate the function of an intracellular protein of interest,particularly in a gain-of-function fashion,remai
Nur77 (aka TR3 or NGFI-B) is an orphan nuclear receptor and plays important roles in carcinogenesis,inflammation,metabolism,and energy homeostasis.However,there
Identification of direct modulators of transcription factor proteinprotein interactions is a key challenge for ligand discovery that promises to significantly a
The secondary metabolites (or natural products),such as flavonoids,steroids,triterpenes,and antibiotics,are frequently post-modified with saccharides.These ubiq
The importance of cell surface oligosaccharides and glycosaminoglycans in signal transduction processes of biomedical significance is now well established.1 Des