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Ghrelin has been identified as the endogenous ligand of the growth hormone secretagogue receptor(GHS-R).Recent studies indicate that vagal afferent dependent mechanisms may be involved in peripheral ghrelin-induced increase in food intake.Intriguingly,peripheral ghrelin has been shown to activate the neurons in the arcuate and the paraventricular of the hypothalamus but not in the dorsal vagal complex(DVC),an area known to receive inputs from vagal afferents.It is as yet unclear how circulating ghrelin would gain access to and influence the activity of the neurons in the DVC in which GHS receptors are expressed.In the present study,neuronal activity was recorded extracellularly in the DVC of anesthetized rats in order to examine the effects of ghrelin on the glucose sensing neurons and the gastric distension(GD) sensitive neurons.