Acetylation of Osx enhances its protein stability, DNA binding ability and transcriptional activity

来源 :第十四次全国医学遗传学学术会议 | 被引量 : 0次 | 上传用户：jnd411525477

【摘要】

：

　　Osterix (Osx) , a C2H2-type zinc-finger containing transcription factor, plays an essential role in controlling osteoblast differentiation and bone formatio

【作者】

：

JianleiLu[1]BingYao[1]YuexinXu[1]YucuiJin[1]KaikaiShi[1]YifangShui[1]ShiyangPan[2]LiChen[3]ChangyanMa[1]

【机构】

：

Department of Developmental Genetics, Nanjing Medical University, Hanzhong Road 140,Nanjing 210029,

【出处】

：

第十四次全国医学遗传学学术会议

【发表日期】

：

2015年期

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　　Osterix (Osx) , a C2H2-type zinc-finger containing transcription factor, plays an essential role in controlling osteoblast differentiation and bone formation.The precise molecular regulation of Osx expression is still not fully understood.Here, we studied the post-translational regulation of Osx by acetylation.

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Acetylation of Osx enhances its protein stability, DNA binding ability and transcriptional activity

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