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This paper documents the first attempt to apply the singular boundary method(SBM)with time-dependent fundamental solution to transient diffusion equations.An inverse interpolation technique is introduced to determine the origin intensity factor of the SBM.The scheme is mathematically simple,easy-to-program,truly boundary-only,free of integration and mesh.We also find explicit empirical formulas to directly evaluate the origin intensity factor which further improve the efficiency and accuracy of the present scheme.Several examples are provided to test time-dependent SBM strategy.The numerical results clearly demonstrate its great potential.