【摘 要】
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Paired box 7 (Pax7) gene encoding for the transcription factor can regulate the conversion of stem cells into myogenic cells and participate in the development and regeneration of skeletal muscle.The
【机 构】
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College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Mole
【出 处】
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第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
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Paired box 7 (Pax7) gene encoding for the transcription factor can regulate the conversion of stem cells into myogenic cells and participate in the development and regeneration of skeletal muscle.The aims of this study were to detect variations of Pax7 gene by DNA pool sequencing and aCRS-RFLP methods in 1441 cattle from five breeds and to investigate their associations with growth traits in Nanyang and Chinese red steppe cattle.Altogether, three novel single nucleotide polymorphisms (SNPs) were identified in the last intron of Pax7 gene: NC_007300: ssl (g.G103688A), ss2 (g.T103735C), and ss3 (g.A103764T).Genotypes and the referring haplotypes frequencies showed high similarity trend among five breeds, and the allele G, T and A frequencies of the three loci were always superior when in separate or combinations.Association analysis of the single SNPs and haplotypes combinations revealed that the T allele of ss2 and ss3 and the haplotype H2H2 (GG-TT-TT) showed significant effects on growth traits such as body height, body weight and chest girth in cattle at early stages (6/12 months old) (P<0.05).The results showed that Pax7 gene variations and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
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