【摘 要】
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Forkhead box A2 (Foxa2) has been recognized as one of the most potent transcriptional activator that is implicated in the control of feeding behavior and energy homeostasis.However, similar researches
【机 构】
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College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Mole
【出 处】
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第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
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Forkhead box A2 (Foxa2) has been recognized as one of the most potent transcriptional activator that is implicated in the control of feeding behavior and energy homeostasis.However, similar researches about the effects of genetic variations of Foxa2 gene on growth traits are lacking.Therefore, this study detected Foxa2 gene polymorphisms by DNA pool sequencing, PCR-RFLP and PCR-ACRS methods in 822 individuals from three Chinese cattle breeds.The results showed that four sequence variants (SVs) were screened, 3including two mutations (SV1, g.7005 C>T and SV2, g.7044 C>G) in intron 4, one mutation (SV3, g.8449 A>G) in exon 5 and one mutation (SV4, g.8537 T>C) in the 3UTR.Notably, association analysis of the single mutations with growth traits in total individuals (at 24 months) revealed that significant statistical difference were found in four SVs, and SV4 locus was highly significantly associated with growth traits throughout all three breeds (P<0.05 or P<0.01).Meanwhile, haplotype combination CCCCAGTC also indicated remarkably associated to better chest girth and body weight in Jiaxian Red cattle (P<0.05).We herein described a comprehensive study on the variability of bovine Foxa2 gene that was predictive of molecular markers in cattle breeding for the first time.
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