【摘 要】
：
Coronary vasospasm (CVsp) plays an important role in the pathogenesis not only of variant angina but also of ischemic heart disease, including effort angina, unstable angina, acute myocardial infarcti
【机 构】
：
Internal Intensive Care Unit Taipei Medical University-Shuang Ho Hospital Taiwan
【出 处】
：
BITs 1rd Annual World Cancer Congress of Cardiology-2009(200
论文部分内容阅读
Coronary vasospasm (CVsp) plays an important role in the pathogenesis not only of variant angina but also of ischemic heart disease, including effort angina, unstable angina, acute myocardial infarction and sudden death.However, similarities and differences between CVsp and atherosclerotic coronary artery disease (CAD) are not known.We recently found that there is an interaction between smoking and high-sensitivity C-reactive protein (hs-CRP) in CVsp development.Therefore, we further retrospectively enrolled more patients to determine whether there was a gender difference in the development of CVsp and a secondary goal was to ascertain whether there were interactions among gender, age, hypertension and hs-CRP influencing the prediction of CVsp development among patients without obstructive CAD.In women, only the highest hs-CRP tertile (>3 mg/1) was independently associated with CVsp.In men, age >58 years and the highest hs-CRP tertile were independently associated with CVsp.In women, elevated risk was only demonstrated in patients ≤58 years with hs-CRP levels in the highest tertile.In men, a positively monotonic trend was demonstrated between hs-CRP levels and CVsp in those >58 years.The odds ratios of CVsp in both women and men with hs-CRP in the highest tertile reduced from 6.01 to 1.48 and 6.35 to 2.69, respectively, if they had hypertension.This study suggests that the relationship between hs-CRP and CVsp differed between men and women.Our findings that there is a non-threshold model in men and a threshold model in women provide evidence that more smokers in men (life-style) and age (induction time) contribute to the natural history of CVsp development.Furthermore, the negative effect of hypertension on CVsp suggests that the pathogenesis of CVsp differs from that of coronary atherosclerosis.
其他文献
Several studies indicated that chronic kidney disease (CKD) is an independent risk factor for developing cardiovascular disease (CVD), so it is not surprising that the prevalence of CKD in patients wi
Sleep disordered breathing (SDB) in the form of obstructive sleep apnea (OSA), central sleep apnea (CSA) and Cheyne Stokes respiration (CSR) are the leading cause of pulmonary arterial hypertension (P
Both diabetes (DM) and metabolic syndrome (MetS) have been associated with an increased risk for mortality from all-causes, cardiovascular diseases (CVD) and coronary heart disease.Moreover, CVD is th
Cardiovascular complications represent 60% of the causes of death in patients with type 2 diabetes.Several causes may explain this mortality excess and among these, the decreased availability of nitri
FH is an inherited condition resulting in markedly elevated LDL-c leading to early mid life CAD.The aims of the study were to evaluate the effectiveness of long term lipid lowering therapy on LDL-c le
Apoptosis or proliferation of vascular smooth muscle cells (VSMCs) within atherosclerotic plaques is either beneficial or detrimental to lesion development and depends on the stage and localisation of
Perturbation of energy and lipid homeostasis plays a central role in the pathogenesis of heart disease.Primary and/or secondary alterations of lipid metabolism pathways in various pathological conditi
Oxidized Low-Density Lipoproteins (oxLDLs), autoantibodies (oxLDL Ab) and HLA-DRB1 may play an important role in the immune-related atherosclerosis.Two hundred subjects were recruited and demographic
The interest of CRP in CHD arises from its long half life and the robustness and reliability of its assessment.To date, CRP is the inflammatory marker most extensively assessed in prognostic studies,
To sort out patients with serious or even life-threatening diseases from the vast majority of chest pain patients with trivial diseases is a very important task for emergency physicians.Accurate labor