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@@ Sonazoid has been launched in Japanese market in 2007. During these five years, Sonazoid has been administered to more than 250,000 patients. There is no fatal side effect such as anaphylaxis shock.Application of Sonazoid is limited to diagnosis of liver tumorous diseases in terms of insurance reimbursement. This is because of that efficacy and safety of Sonazoid have been proved in clinical trials only in diagnosis of liver tumorous diseases.