【摘 要】
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Uridine is a potential endogenous neuromodulator studied for several decades for its antiepileptic effect,but the results were controversial.One remarkable feature of uridine is its regulatory action
【机 构】
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Department of clinical Pharmacy,Chinese PLA General Hospital,Fuxing Road 28＃,100853,Beijing,PR China
【出 处】
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2017年中国药学大会暨第十七届中国药师周
论文部分内容阅读
Uridine is a potential endogenous neuromodulator studied for several decades for its antiepileptic effect,but the results were controversial.One remarkable feature of uridine is its regulatory action on the dopaminergic pathways.In this study,the changes in uridine and dopamine(DA)release were examined in the mouse corpus striatum epileptic model using an intraperitoneal injection of pilocarpine(PC).Then,the effect of uridine pretreatment on DA release and expression of dopamine receptor(DR)was determined.The results revealed an increased uridine release initially,followed by a downward trend.However,the DA release increased significantly after an injection of 300-mg/kg PC; the expression of dopamine receptor-1(D1R)increased in a dose-dependent manner while that of dopamine receptor-2(D2R)decreased significantly.Prophylactic administration of uridine significantly relieved the high-frequency and high-amplitude expression induced by PC as well as dose-dependently reversed the PC-induced changes in DA and DR levels.These findings suggested that uridine pan antiepileptic effect, which might have been mediated in part by interfering with the dopaminergic system.
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