Regulatory divergence of duplicate genes in maize

• 作 者: Lin Li Roman Briskine Robert Schaefer Michael Scanlon Marja C.P.Timmermans Patrick S.Schnable Jianming Yu Chad L.Myers Lex Flagel Nathan M.Springer Gary Muehlbauer
• 机 构: Department of Agronomy and Plant Genetics,University of Minnesota,Saint Paul,Minnesota,USA
• 出 处: 第一届全国玉米生物学学术研讨会
• 发表日期: 2015年5期

Gene duplication exists in nearly all species and can result in coding and regulatory divergence.In maize,whole genome duplication (WGD) resulted in the subgenomes maize 1 and maize2,with maize 1 the dominant genome.One unanswered question is the regulatory fate of duplicated genes in gene co-expression networks.To address the consequence of gene duplication on regulatory divergence,we first developed a gene co-expression network from RNA-seq data derived from 64 different tissues/stages of the reference inbred-B73.Next,we used the reference B73 sequence to identify three duplication types:WGD,tandem and inserted (non-syntenic) based on maize syntenic gene blocks and related these duplicated genes to the gene co-expression network.Interestingly,the inserted duplicate genes were less likely to be expressed and more likely to be singletons in the co-expression network,while WGD duplicate genes are expression-prone and likely to be connected in co-expression network.Tandem duplicate genes exhibited moderate expression variation compared with WGD and inserted duplicate genes.