Heme acts a signaling molecule to regulate exocrine peptidase precursor genes in zebrafish

来源 :第二届中国国际生物微量元素大会 | 被引量 : 0次 | 上传用户：myulyx

【摘要】

：

　　Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine

【作者】

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Han Wang

【机构】

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CenterforCircadianClocks,SoochowUniversity,Suzhou215123,Jiangsu,China

【出处】

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第二届中国国际生物微量元素大会

【发表日期】

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2014年11期

【关键词】

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Bach1b Nrf2a MafK Heme Porphyria Zymogens Zebrafish

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　　Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine zymogens.Zebrafish bachlb, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas.Overexpression of bachlb or knockdown of nrf2a result in the downregulation of the expression of the exocrine zymogens, whereas overexpression of nrf2a or knockdown of bachlb cause their upregulation.

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Heme acts a signaling molecule to regulate exocrine peptidase precursor genes in zebrafish

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