【摘 要】
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Background No definitive comparative studies of the efficacy of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinsons disease (PD) under general anesthesia (GA) in mainland of China.Me
【机 构】
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Department of Neurology, First Affiliated Hospital, Sun Yat-sen University,Guangdong Key Laboratory
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Background No definitive comparative studies of the efficacy of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinsons disease (PD) under general anesthesia (GA) in mainland of China.Method 32 patients were assigned to the GA group and 16 patients were assigned to the LA group, we compared the middle-term outcome of patients under GA with those who were operated on under local anesthesia (LA) after at least 6 months after surgery.Result Motor outcome: There was no significant difference on the UPDRSIII scores in either groups in 6 months fellow-up.Non-motor outcome: The overall non-motor outcome did not show difference except that the levodopa equivalent daily dose (LEDD) showed a greater decline in GA group, the score of MOCA was improved in LA group and the score of NMSS better in GA group in 6 months fellow-up.Adverse effects: There was no significant difference on the incidence of adverse effects in either groups except that the incidence of temporary hiccup was significantly higher in the GA group.Conclusion Asleep-DBS can be considered as a good alternative method for PD patients undergoing DBS.although DBS under general anaesthesia may lead to more treatment-induced side effects, a significant greater decline in LEED may be seen in the GA group.
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