【摘 要】
：
Background: Parkinsons disease(PD) is a neurodegenerative disease.With the progress of the disease, the symptoms gradually worse and levodopa-induced motor complication arise.Deep brain stimulation(DB
【机 构】
：
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University,Guangdong Key Laboratory
论文部分内容阅读
Background: Parkinsons disease(PD) is a neurodegenerative disease.With the progress of the disease, the symptoms gradually worse and levodopa-induced motor complication arise.Deep brain stimulation(DBS) is an effective treatment for advanced PD.There are some RCT researches for short term efficacy for DBS as well as some long term study in foreign.But its long term efficacy have been little formulated in China, although China occupies the largest proportion of PD patients.Objective: To investigate the long term efficacy and its safety of STN DBS for PD in China with an eight years follow up of nine patients.Methods: Patients with PD who had recieved bilateral STN DBS, was assessed preoperatively(baseline) and 1, 3, 5 and 8 years postoperatively on medication and without medication, using the Unified Parkinsons disease Rating Scale (UPDRS) and a series of neruopsychological assessment.At the same time, the levodopa equivalent daily dose (LEDD) and stimulating parameter were also recorded.
其他文献
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone and cartilage erosion.Synovial fibroblast-and T cell-mediated inflammation plays c
This study aimed to investigate efficacy and safety of iguratimod (T-614) in combination with methotrexate (MTX) for active rheumatoid arthritis (RA) patients.Sixty active RA patients were enrolled ac
目的：检测多发性硬化(MS)患者外周血淋巴细胞(PBMC)中辅助性T细胞17 (Th 1 7)特异性转录因子维甲酸相关核孤儿受体γ t(RORγ t)、B细胞转录激活因子(BATF)及外周血中Th17细胞相关细胞因子白细胞介素10(IL-1O)、白细胞介素17(IL-17)和白细胞介素27(IL-27)表达水平,探讨其在MS发病中的作用.方法：以缓解-复发型多发性硬化急性发作期患者及健康对照组各5
目的：多颅神经损害的病因多种,淋巴瘤很少见。系统性非霍奇金淋巴瘤早期临床表现无特异性,以多颅神经损害为主要表现的病例少见,总结其病例特点,提高早期诊断正确率。方法：回顾性分析5例以多颅神经损害为主要表现的系统性非霍奇金淋巴瘤的临、影像学、脑脊液细胞学以及病理活检结果。结果：5例以多颅神经损害为主要表现的系统性非霍奇金淋巴瘤患者,最后经病理活检确诊3例为弥漫大B细胞淋巴瘤,1例为Burkitts淋巴
目的：探讨癫痫患者发作间期,其痫样放电对其认知功能的影响,进一步了解痫样放电,为癫痫治疗提供理论参考.方法：选取癫痫患者36例,根据8h以上视频脑电图测定,将其分16例为脑电图正常组,20例发作间期痫样放电组,运用数字符号转换测验、连线测验、数字广度测验以及语言流畅性测验等神经心理量表行认知功能测定,以统计学软件SPSS17.0行统计分析.结果：痫样放电组数字符号、语言流畅性、数字广度均比脑电图正
目的：探讨脊髓小脑性共济失调34型(SCA34)患者的临床特征及其分子遗传学特点。方法：总结2例SCA34患者的症状、体征、颅脑磁共振表现以及基因检测结果，并综合相关文献进行分析。结果：本文2例患者均具有明显共济失调、步态不稳、构音障碍、眼球震颤等症状，颅脑磁共振检查可见明显小脑萎缩表现。基因分析结果提示：先证者SCA1、2、3、6、7、8、12、17型基因座上的CAG重复数均未超过正常范围。高通
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by interactions between environmental factors and genetic susceptibility.Sleep disorders such as circadian rhythm dysfun
背景 关于无症状颈内动脉狭窄的治疗策略存在着明显争议.我们的meta分析探讨比较手术(颈内动脉内膜切除术或者颈内动脉支架植入术加药物和单纯药物治疗无症状颈内动脉狭窄患者的安全性和疗效性.方法 检索Pubmed,Ovid EBM Reviews数据库以及Food and Drug Administration documents,收集手术加药物治疗和单纯药物治疗无症状颈内动脉狭窄研究文献(收集年限到
目的：探讨重度牙周炎与早期卒中后抑郁的相关性.方法：收集2015年12月至2016年12月在粤北人民医院卒中单元诊治的急性缺血性卒中患者202例.入院当天完成美国国立卫生研究院脑卒中量表(National Institute of Health Stroke Scale,NIHSS)评分.1周内,完善患者临床资料和常规实验室检查及辅助检查,并由口腔科医师完善牙周检测.入院2周内,根据《精神疾病诊断
目的 探讨局灶性内囊梗死后锥体束的弥散张量和皮层运动网络的静息态功能连接(resting state-Functional Connectivity, rs-FC)的变化及其意义。方法 19例单部位内囊梗死的患者作为实验组和19例匹配的正常人作为对照组。两组均在发病后第7天(D7)、30天(D30)、90天(D90)行DTI和rs-fMRI扫描,同时行神经功能评分：美国国立卫生研究院卒中评分(na