Halofuginone Regulates Autophagy and Glucose Metabolism for Anti-colorectal Cancer

来源 :2016上海脂代谢与疾病国际研讨会 | 被引量 : 0次 | 上传用户：anlyok

【摘要】

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【作者】

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Guo-Qing Chen Shu-Hai Lin Zhao-Xiang Bian

【机构】

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School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China

【出处】

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2016上海脂代谢与疾病国际研讨会

【发表日期】

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2016年9期

【关键词】

：

halofuginone autophagy glucose metabolism nutritional conditions colorectal canc

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Interlinked autophagy and metabolism opens a new therapeutic window in cancer.Recently,we found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC).But whether and how HF regulates autophagy and metabolism to inhibit cancer growth remains an open question.Here,we unveil that HF regulates nutrient-sensing mTORC1/AMPK for autophagic flux and glucose metabolism in CRC cells.

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Halofuginone Regulates Autophagy and Glucose Metabolism for Anti-colorectal Cancer

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