【摘 要】
：
Objective: In breast cancer, PARP inhibitors have been developed as single-agent in BRCA1/2-mutated tumors or in combination with chemotherapy.For optimization of PARP inhibitor treatment for cancer,
【机 构】
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Division of Genome Stability Research,National Cancer Center Research Institute,Tokyo,Japan;Departme
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: In breast cancer, PARP inhibitors have been developed as single-agent in BRCA1/2-mutated tumors or in combination with chemotherapy.For optimization of PARP inhibitor treatment for cancer, to further investigate the molecular function of PARP-1 in DNA repair is important.We previously reported that PARP-ldeficiency caused increase deletion mutations and insertions or rearrangements after being treated with an alkylating agent.These deletion mutations,insertions, and rearrangement could be produced by alowfidelity of double-stranded-DNA break (DSB) repair, especially nonhomologous end-joining (NHEJ).NHEJ is an important process to stabilize DNA end-joining synapsis; therefore, to figure out the function of PARP-1 in DSBs during NHEJ is very important.
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