TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：cxz2004

【摘要】

：

Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves cleavage of amyloid precursor protein(APP)by γ-secretase,a protease known to cleav

【作者】

：

Junfeng Wang Rui Lu Jian Yang Hongyu Li Zhuohao He Qian He Yuqing Wang Naihe Jing Xiaomin Wang Yizheng Wang

【机构】

：

Laboratory of Neural Signal Transduction,Institute of Neuroscience,SIBS,State Key Laboratory of Neur

【出处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

TRPC6 Alzheimer’s disease β-amyloid

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TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio

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