【摘 要】
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Pancreatic b-cell dysfunction is a common feature of type 2 diabetes.Earlier,we had cloned IG20 cDNA from a human insulinoma and had shown that IG20/MADD can encode six different splice isoforms that
【机 构】
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Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago,Ch
【出 处】
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华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
Pancreatic b-cell dysfunction is a common feature of type 2 diabetes.Earlier,we had cloned IG20 cDNA from a human insulinoma and had shown that IG20/MADD can encode six different splice isoforms that are differ-entially expressed and have unique functions,but its role in b-cell function was unexplored.To investigate the role of IG20/MADD in b-cell function,we generated condi-tional knockout (KMA1ko) mice.Deletion of IG20/MADD in b-cells resulted in hyperglycemia and glucose intoler-ance associated with reduced and delayed glucose-induced insulin production.
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