【摘 要】
:
BACKGROUND AND PURPOSE The orphan nuclear receptor Nur77 is implicated in the survival and apoptosis of cancer cells.The purpose of this study was to determine whether and how Nur77 serves to mediate
【机 构】
:
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
【出 处】
:
华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
BACKGROUND AND PURPOSE The orphan nuclear receptor Nur77 is implicated in the survival and apoptosis of cancer cells.The purpose of this study was to determine whether and how Nur77 serves to mediate the effect of the inflammatory cytokine TNF-α in cancer cells and to identify and characterize new agents targeting Nur77 for cancer therapy.
其他文献
Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development.We now report that,in mouse cortical neurons,Cdk5 is capable of pho
Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimers disease (AD).Aβ is generated from amyloid-β precursor protein (APP) through sequ
Searching and evaluating the Human Protein Atlas for transmembrane proteins enabled us to identify an integral membrane protein,TMEM115,that is enriched in the Golgi complex.Biochemical and cell biolo
U12,one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA),has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2) and to protect normal liver cells from
目的 为了促进难溶性药物西罗莫司(sirolimus,SRL)的口服吸收,制备西罗莫司自微乳化微丸(SRL-SMEDDS pellets,SSP),并对其进行体内外评价.方法 通过溶解度试验确定助乳化剂、油相和乳化剂的选择范围;三元相图法及星点设计和效应面法对该体系优化制备工艺及处方.挤出-滚圆法制备了不同处方的西罗莫司自微乳化微丸(1,22.4,38.4,19.2,121.6,30.4和8毫克的
目的 研究他克莫司温敏眼用凝胶对家兔角膜移植术后排斥反应的治疗效果.方法 随机对青紫兰兔32只位受体及大耳白兔16只为供体建立的穿透性角膜移植模型分为4组(A到D,每组8只),A组为对照组,给以生理盐水,B-D组分别为环孢素滴眼液、他克莫司蓖麻油滴眼剂、他克莫司温敏眼用凝胶.以角膜植片混浊、水肿及新生血管评分之和为角膜排斥反应指数(RI),,观察角膜移植术后植片排斥反应指数(rejection i
Metabolic reprogramming is fundamental to biological homeostasis,enabling cells to adjust metabolic routes after sensing altered availability of fuels and growth factors.ULK1 and ULK2 represent key in
目的 研究环孢素A对家兔角膜移植术后排斥反应的治疗效果.方法 随机对青紫兰兔32只位受体及大耳白兔16只为供体建立的穿透性角膜移植模型分为4组(A到D,每组8只),A组为对照组,给以生理盐水,B-D组分别为1%环孢素眼用亚微乳剂、0.025%地塞米松滴眼液、1%环孢素眼用亚微乳剂+0.025%地塞米松滴眼液.以角膜植片混浊、水肿及新生血管评分之和为角膜排斥反应指数(RI),,观察角膜移植术后植片排
Differentiation of oligodendrocyte precursor cells (OPCs) is a prerequisite for both developmental myelination and adult remyelination in the central nervous system.The molecular mechanisms underlying
目的 建立HPLC-UV法测定配制的TA-2014-026注射液浓度的方法,并对该分析方法进行验证.方法 采用HPLC-UV法,其色谱条件选用phenomenex Luna 5μC18柱(150×4.6mm)为色谱柱、0.6%乙酸水溶液∶甲醇=30∶70为流动相、流速为1mL/min、检测波长为275nm、灵敏度为0.05AUFS、柱温为40℃和进样体积为10uL.验证方法的专属性、系统适用性、标