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Cellulose is the earth(A)s most widespread rertewable resource occurring at a volume of 700 billion tons.Value-promoting utilization of cellulose has aroused extensive attention throughout the world.Sulfation modification contributed to transferring cellulose into bio-active form cellulose sulphate(CS),which showed anticoagulant,antibacterial and antiviral activities.Increasing the degree of sulfation (DS) and improving the distribution of sulphate groups along cellulose main chain are crucial for the activity.