A versatile base editing tool without sequence preference for studying regulatory genomic elements

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：lishine369

【摘要】

：

Objective The genome holds extraordinary information.However,only 1.5%or less of mammalian genomes consist of protein-coding sequence.The rest of the genome,consisting of noncoding sequences,was once

【作者】

：

shuzhen zhang Jieping Chen

【机构】

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Department of Hematology,Southwest Hospital,Army Medical University

【出处】

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2019中国肿瘤学大会

【发表日期】

：

2019年7期

【关键词】

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CRISPR-based base editing BE-PLUS(AID) G-quadruplex

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　　Objective The genome holds extraordinary information.However,only 1.5%or less of mammalian genomes consist of protein-coding sequence.The rest of the genome,consisting of noncoding sequences,was once considered as “junk DNA”,but is now appreciated to harbor large numbers of functional genomic elements that remain to be extensively explored.

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A versatile base editing tool without sequence preference for studying regulatory genomic elements

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