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  5. Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertroph

Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertroph

来源 :Ready for 2018- the 4th China International Forum on Hyperte | 被引量 : 0次 | 上传用户：bhf10116
【摘 要】
：
Objective:Cyclins/retinoblastoma protein (pRb) pathway participates in cardiomyocyte hypertrophy.MicroRNAs (miRNAs), the endogenous small noncoding RNAs, were recognized to play significant roles in c
【作 者】
：
Shuai Huang Jiening Zhu Yongheng Fu Qiuxiong Lin Chunyu Deng Sujuan Kuang Mengzhen Zhang Zhixin Shan 
【机 构】
：
Medical Research Department of Guangdong General Hospital,Guangdong Cardiovascular Institute,Guangdo
【出 处】
：
Ready for 2018- the 4th China International Forum on Hyperte
【发表日期】
：
2015年3期
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Objective:Cyclins/retinoblastoma protein (pRb) pathway participates in cardiomyocyte hypertrophy.MicroRNAs (miRNAs), the endogenous small noncoding RNAs, were recognized to play significant roles in cardiac hypertrophy.But, it remains unknown whether cyclin/Rb pathway is modulated by miRNAs during cardiac hypertrophy.This study investigates the potential role of microRNA-16 (miR-16) in modulating cyclin/Rb pathway during cardiomyocyte hypertrophy.
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