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Objective: As an important treatment for thoracic cancers, radiotherapy (RT) can cause definite cardiotoxicity, even with modem techniques, such as 3D-CRT and IMRT.This prospective study was initiated to assess radiation-induced heart disease (RIHD) during-RT (at 40Gy) using gated 99mTc-sestamibi (MIBI) single photon emission computed tomography (SPECT) in patients with esophageal cancer.This ongoing study aimed to investigate the value of 99mTc-MIBI SPECT in the detection of RIHD as early as during-RT.