【摘 要】
：
Purpose: To study in vitro transdermal permeability of amlodipine base (AM), amlodipine besilate (AM-B), amlodipine adipate (AM-A), amlodipine oxalate (AM-O) and amlodipine maleate (AM-M) from the EI
【机 构】
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Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Webhua Road, Shenyang
【出 处】
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首届亚洲药物制剂科学研讨会(1st Asian Pharmaceutical Science and Technolog
论文部分内容阅读
Purpose: To study in vitro transdermal permeability of amlodipine base (AM), amlodipine besilate (AM-B), amlodipine adipate (AM-A), amlodipine oxalate (AM-O) and amlodipine maleate (AM-M) from the EI system (ethanol: isopropyl myristate (IPM) =2∶8) through excised rat skin.Methods: First, AM was prepared from AM-B, then AM-M, AM-A, and AM-O were prepared using AM and the corresponding organic acids.Differential scanning calorimetry (DSC) thermograms of AM and its complexes were studied to demonstrate the formation of complexes.The permeation characteristics of AM and its complexes were evaluated using 2-chamber diffusion cells.Results:AM shows the highest steady-state flux (Js) among AM and its complexes.Conclusion: AM is the best candidate for development of transdermal drug delivery system (TDDS).
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