论文部分内容阅读
Purpose: Microparticulate delivery systems designed for the nasal administration of the anticancer drug, methotrexate, were prepared.Methods: MTX/chitosan complex microspheres were prepared by ionic crosslinking method.The complexation efficiency, size distribution, and IR spectrum were evaluated.Results: High drug complexation efficiency could be obtained by careful control of the formulation PH.And it did not occur in the highest ionization range of the model drug.IR results also indicated the formation of the complex.Conclusion: The ionic crosslinking was a simple, mild method.It avoided using any organic solvents and was suitable for nasal administration.