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The proliferative effects of pilose antler extract (PAE)on rat osteogenic cells UMR-106 were investigated in vitro.Component P2 of PAE was isolated by Sephacryl S-200HRgel filtration chromatography.The proliferative effects of P2 and other components isolated by Sephacryl S-200HR on UMR-106 cells were investigated by MTT assay.Results showed that the P2 could significantly increase the proliferation rate of osteogenic cells.