Multiplexing Technology to Measure "Biomarkers" in Biological Fluids

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户:QQ359780695
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Cytokines,hormones,and growth factors in biological fluids are critical factors (biomarkers) in the manifestation and treatment of numerous disorders.Measurement of these multiple analytes in patient sera has been shown to have a strong correlation to clinical data including disease activity,diagnosis,and therapeutic response.Traditional ELISA methods for measuring these factors are costly,time-consuming and require large volumes of valuable samples for measuring multiple analytes.It is,therefore,difficult to obtain a systematic profile of multiple "biomarkers" involved in any specific disease state.This seminar will review the advantages of Multiplexing to measure multiple analytes in one small volume serum sample using the Luminex xMAP technology.In addition,the presentation reports on the developments and results achieved with a variety of diseases in human,non-human primate,mouse,rat and canine species specific screening panels.Disease panels that will be discussed include endocrine/metabolic diseases,cardiovascular,inflammation,and cell signaling.
其他文献
1948年,中共重庆地下党组织因市委高层领导叛变,遭到毁灭性的破坏。正在某大学工作的地下党支部书记吕坪接到紧急转移的命令,和一个化装成妻子的女地下党员,在阴霾密布的夜里
  Natural products have played a critical role in the identification of numerous medicines.Historically the pharmaceutical industry has been challenged with p
会议
  Metabolic Biomarkers have been utilized in different fields of medicine for years.Recent developments in mass spectrometry coupled with different separation
会议
麝香秋葵别名山油麻,锦葵科一年生植物。株高93~134厘米,茎圆柱形,叶互生,卵圆形有缺裂。开两性黄花,花后6~8天坐果,果实为蒴果,筒状,似羊角,有5~6裂。长至12~15厘米时可食用。种子成熟后为褐色,千粒重60克
农业资源高效管理是实现我国农业资源可持续开发利用的一项必要措施.提高各级农业科研机构的信息化水平及农业资源利用和管理效率,将有利于促进我国现代化农业管理体系的建设
  Building on a previously disclosed PDE4 inhibitor,NVP-ABE171 (1),new compounds were synthesised with significant improvements in physico-chemical properties
会议
  Molecular docking is a very powerful tool to investigate drug poses onto their specific targets.Yet,there are many cases for which these standard procedures
会议
  Viral membrane proteins are responsible for viral entry and modulation of the host cell.The proteins have to assemble either with themselves or host factors
会议
大棚角瓜复种秋葱,省工,易管理,经济效益高,一直被我乡农民接受,其栽培技术要点如下:1 选优良品种角瓜品种选花叶角瓜,2月中旬温室播种育苗,营养土用马粪、大粪面、细炉灰、
  As we are entering the age of "Personal Genomics" or "Personalized Medicine",it has been expected that the knowledge of human genetic polymorphisms and vari
会议