The oncogenic activity of MDMx is associated with physicalinteraction and suppression of retinoblast

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：lnclnc

【摘要】

：

【作者】

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Haibo zhang Yujun Zhang Qiu Wei Zhi-Xiong Xiao

【机构】

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Center of Growth, Metabolism and Aging, College of Life Sciences,Sichuan University, Chengdu, China

【出处】

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

MDMX retinoblastoma protein (Rb)

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The aim of this study is to investigate the role of MDMx (or MDM4) on the regulation ofretinoblastoma protein (Rb).Inactivation of Rb plays a critical role in the development ofhuman malignancies.We have previously shown that MDM2, an ubiquitin E3 ligase and amajor negative regulator of p53, binds to and promotes proteasome-mediated degradationof Rb independent of p53.MDMX, a homolog of MDM2, also binds to and inhibitsp53 transactivation activity, yet it does not possess an ubiquitin E3 ligase activity.

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The oncogenic activity of MDMx is associated with physicalinteraction and suppression of retinoblast

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