MicroRNA-346 Mediates Tumor Necrosis Factor-□-induced Down-Regulation of Vitamin D Receptor in Gut E

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:hongshu16
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibitscolitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelialVDR is markedly down-regulated in patients with inflammatory bowel diseases (IBD), butthemechanism underlying VDR down-regulation in IBD is unknown.
其他文献
In previous studies, iron has been shown to play a significant role in the formation of freeradicals which contributed to oxidative stress, resulting in cell damage.Damage to culturedhepatocytes was p
Ovarian cryopreservation by vitrification is a very effective method for preserving femalesfertility during chemotherapy and radiotherapy, and studying of the gene expressionduring ovarian cryopreserv
Despite of the progress in identifying many Lys acetylation (Kac) proteins, Kac substratesfor Kac-regulatory enzymes remain largely unknown, presenting a major knowledge gap inKac biology.
This study elucidated the role of CaN-NFAT signaling and neurotrophins on thetransformation of myosin heavy chain isoforms in the rat soleus muscle fiber following aerobicexercise training.To do so, w
Uniblue A and its derivatives are a class of low-cost dyes that can be used to covalently labelproteins.The efficiency of staining, in companion with the subsequent detection methods,is critical for t
Yeast Hifl, a homologue of human nuclear autoantigenic sperm protein (NASP), is a histonechaperone that involved in various protein complexes modifying histones during telomericsilencing and chromatin
Endothelial cells are the inner mono-layer cells of the blood vessels, playing critical roles toseparate blood from underlying tissues.Endothelial cells form a dynamic and selective permeabilitybarrie
Objective: To analyze the expression characteristics of mouse spermatogenesis-related gene SRPK2 and to reveal its molecular roles during spermatogenesis.
The Hippo signalling pathway can suppress the Wnt/β-catenin signalling pathwayt h r o u g h t h e 1 a s t d o w n s t r e a m e f f e c t o r s Y A P (Y e s-a s s o c i a t e d p r o-tein)/TAZ(tafazzi
The transcription factor NF-κB acts as a critical regulator in innate and adaptive immunesystem in response to a variety of stimuli, therefore both activation and inactivation of NF-κB signaling neede