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Infertility is marked by its ambiguous nature which is considered as an invisible obstacle, blocking couples from assuming new family developmental roles.Couples would seek all sorts of help such as in vitro fertilization (IVF) to resolve their infertility.During the IVF process, child(ren) would be psychologically present in couples mind, while they are physically absent in reality.The dissonance created by infertility of being psychologically present and physically absent at the same time is coined as ambiguous loss (Boss, 1999).Infertile couples reported they found it difficult to mourn over their ambiguous loss because there were few socially established norms and traditionally recognized rituals in infertility, and that they felt disenfranchised in the grieving process.This study examined the efficacy of a 4-session group intervention, adopting the Integrative Body-Mind-Spirit (I-BMS) model, which aims to help infertile women transform the loss and reconstruct their meaning of family and life in the context of involuntary childlessness.A randomized controlled study of 339 infertile women undergoing IVF was conducted (intervention: n =172;control: n =167).Assessments of perceived importance of childbearing and spiritual well-being were made at randomization (T0) and after group intervention (T1).Interaction analyses showed women in the intervention group reported lower levels of life disorientation, higher level of tranquility and perceived childbearing as less important compared to those in the control group.These findings suggest that I-BMS was successful at enhancing spiritual well-being of infertile women by reconstructuring their meaning of life and family.