【摘 要】
：
One of the most common routes of HIV-I spread is via heterosexual transmission through mucosal surfaces.To combat this spread,prophylactic topical microbicides are being developed to prevent vaginal a
【机 构】
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Department of Molecular Biology and Microbiology, Bumett College of Biomedical Sciences, University
【出 处】
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2006中国天津世界艾滋病日科技会议
论文部分内容阅读
One of the most common routes of HIV-I spread is via heterosexual transmission through mucosal surfaces.To combat this spread,prophylactic topical microbicides are being developed to prevent vaginal and other mucosal transmission of HIV-Ⅰ.Topical microbicides are self-applied,which has the advantage of empowering vulnerable receptive partners to take effective measures for their own protection.In a search for candidate topical microbicides we discovered that the antimicrobial peptide,retrocyclin,can potently prevent infection of CD4+ cells by both X4 and R5 HIV-Ⅰ.While many studies have utilized simulants of mucosal fluid to test compounds,we demonstrate how whole human vaginal fluid and its functional components affect the activity and stability of retrocyclin peptides.
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