【摘 要】
：
[Background]: Most clinical pathways in treating cancers in Japan are based on individual physicians personal experiences rather than on an empirical analysis of clinical data such as benchmark compar
【机 构】
：
Chiba Cancer Center Japan
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
[Background]: Most clinical pathways in treating cancers in Japan are based on individual physicians personal experiences rather than on an empirical analysis of clinical data such as benchmark comparison with other hospitals.Therefore, these pathways are far from being standardized.Objective: By comparing detailed clinical data from five cancer centers, we have observed various differences among hospitals.By conducting benchmark analyses, providing detailed feedback to the participating hospitals and by repeating the benchmark year later, we strive to develop more standardized clinical pathways for the treatment of cancers.[Method]: The Cancer Quality Initiative (CQI) was launched in 2007 by five Japanese cancer centers (Chiba, Tochigi,Aichi, Kanagawa and Shioku cancer centers).The diagnosis procedure combination (DPC) system was introduced in Japan in April 2003.Using DPC data, the member hospitals benchmarked their pre-operative and post-operative length of stays, the duration of antibiotics administrations and the post-operative fasting duration for gastric, colon,and rectal cancers.The benchmark was conducted by disclosing hospital identities and performed using 2007 and 2008 data.[Results]: In the 2007 benchmark, substantial differences were shown among five hospitals in the treatment of gastric,colon and rectal cancers.After providing the 2007 results to the participating hospitals and organizing several brainstorming discussions, significant improvements were observed in the 2008 data study.[Conclusion]: The benchmark analysis of clinical data is extremely useful in promoting more standardized care and,thus in improving the quality of cancer treatment in Japan.By repeating the benchmark analyses, we can offer truly clinical evidence based higher quality standardized cancer treatment to our patients.
其他文献
Soft tissue angiofibroma is a recently delineated tumor type of unknown cellular origin.Cytogenetic analysis of four cases showed that they shared a t(5;8)(p1 5;q1 3).In three of them it was the sole
DNMT methyltransferase 1 (DNMT1) plays a significant role in maintaining DNA methylation status.Aberrant DNA methylation is a recognized feature of human cancers, and folate is directly involved in DN
Activation of hypoxia signaling pathways is strongly associated with poor prognosis in cancer.Inactivation of the tumor suppressor gene encoding fumarate hydratase causes activation of hypoxia signali
Acacetin (5,7-dihydroxy-4-methoxyflavone), a flavonoid compound, has anti-peroxidative and anti-inflammatory effects.The effect of acacetin on antimetastasis in human prostate cancer DU-145 cells was
Over the years, our work has highlighted the critical role of an altered redox metabolism on cell survival and death signaling in cancer cells (Clement, M-V.and Pervaiz, S.2007).Using a variety of mod
Mitochondria are emerging as intriguing targets for anti-cancer agents.Vitamin E succinate (VES) has been shown to efficiently kill different types of cancer cells.A mitochondrially targeted analogue
In the upper aero-digestive tract mucosa, including the oral cavity, squamous cell carcinoma (SCC) represents 85-90% of malignant neoplasia.For decades there has been little improvement in patient pro
p53 is frequently mutated by genetic alternation or suppressed by various kinds of cellular signaling pathways in human cancers.Recently, we have revealed that p53 is suppressed and eliminated from ce
Active glutamine utilization is a major biochemical feature of most tumor cells and is fundamental for the survival and proliferation of tumor cells.Glutaminolysis represents the first and rate-limiti
Epithelial mesenchymal transition and metastasis are closely related.Aberrant activation of the signaling events involved in these inter-related pathways plays a major pathophysiological role in cance