【摘 要】
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Recent surge of interest in herbal medicine for inflammatory bowel diseases has prompoted us to investigate the anti-inflammtory effects of curcumin and its
【机 构】
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Departments of Biochemistry and Pharmacology Faculty of Medicine,Kuwait University Kuwait
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Recent surge of interest in herbal medicine for inflammatory bowel diseases has prompoted us to investigate the anti-inflammtory effects of curcumin and its mechanism in experimental colitis.Expression of Toll like receptor-4 (TLR4),MyD88 and NFkB was examined in inflamed colonic tissues.Sprague-Dawley male rats having colitis induced by intrarectal administration of trinitrobenzenesulphonic acid were treated daily with an aqueous suspension of curcumin (100 mg/Kg body weight) or phosphate buffered saline (PBS) 2 hr prior to inducing colitis.Non colitis animals controls received curcumin or PBS in a similar manner.Colonic levels of TLR-4,MyD88 and NFkB proteins were measured using ECL western blot analysis,and TLR-4 mRNA by a competitive RT-PCR method.Curcumin suppressed the induction of TLR-4,MyD88 and NFkB proteins in inflammed colon.Interestingly the expression of TLR-4 mRNA remained unaltered in inflamed.Furthermore inflammatory makers such as mYeloperoxidase activity,malodialdehyde concentrations and colon histology were also significantly reversed by curcumin.These findings suggest that curcumin mediates its effects through that TLR-4 and MyD88 and may serve as therapeutic target in IBD treatment.
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