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Aspirin-intolerant asthma (AIA) is a subtype of asthma induced by non-steroidal anti-inflammatory drugs.The nasal polyps in AIA are postulated to have common pathogenic features involving aspirin sensitivity that would be reflected in the DNA methylation profile of AIA polyps.Genome-wide DNA methylation level of nasal polyps from five AIA was examined using microarray technology in comparison with four aspirin-tolerant asthma (ATA) patients.Based on the AIA-specific DNA methylation profile of nasal polyp,332 loci (corresponding to 296 genes) were identified with significant increase in methylation and 158 loci (141 genes) showed a significant decrease in AIA nasal polyp tissues.Gene ontology and pathway enrichment analysis revealed that the genes with differentially methylated CpGs were overrepresented in asthma and immune system which may contribute to the pathogenesis of AIA.Nasal polyps of AIA patients appear to have characteristic methylation signatures compared to ATA.The genes and pathways identified in this study likely play roles in the pathogenesis of polyps associated with AIA,and are therefore attractive targets for novel medical therapies.