Disease-related Pathway Identification via Sparse L1/2 Penalized and Biological Network-constrained

来源 :第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 | 被引量 : 0次 | 上传用户:mj830115
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Motivation Identifying genes and pathways indicative of disease is a central problem in genomic research.In recent years, there are vast amount of a priori biological network information organized into public databases.How to incorporate information encoded by the known biological networks or graphs into analysis of numerical data raises challenges, and several regularization methods have been proposed.However, most of these procedures are based L1-norm, the result of L1 regularization is not good enough for spartity, especially in biology research.
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