论文部分内容阅读
Modern subunit vaccines with purified or recombinant antigens are important alternatives to the traditional vaccines.However, there remains a big challenge to elicit potent antibody production and CD8 T cell response.Nanoparticle-based antigen delivery systems have emerged as an innovative strategy to improve the efficacy of subunit vaccines.The present study reported self-assembled cationic micelles based on poly(ethylene glycol)-b-poly (L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu) hybrid polypeptides as a simple and potent vaccine delivery system.