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Background To study the effects and mechanism of high dose atorvastatin on prevention of contrast-induced nephropathy.Methods All 180 patients undergoing CAG and/or PCI were randomly divided into 20 mg atrovastatin group (regular dose atrovatatin groups: n=90) and 80 mg atrovastatin group(high dose atrovatatin groups: n=90).Patients took 80 mg or20 mg atrovastatin in daily 2 or 3 days before operation.The levels of serum creatinine (Scr), blood ureanitrogen (BUN)and high sensitive C-reactive protein (hs-CRP) were accessed before and 12, 24, 48 hours after operation, respectively.