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To investigate the expression and clinical significance of Chemokine CC-motif ligand 18(CCL18)in cutaneous malignant melanoma(CMM),and its correlations with the expression of VEGF and Ki67,fifty-eight tissue samples of CMM and twenty tissue samples of benign melanocytic nevi were collected to examine the expression of CCL18 by Envision immunohistochemical method,and the expression of VEGF and Ki67 in fifty-eight CMM was also detected.The correlations of CCL18 expression level with CMM clinicopathological factors,VEGF and Ki67 were statistically analyzed.We also confirmed cell sources of CCL18 expressed in CMM tissue with immunofluorescence.