【摘 要】
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The interaction between blood flow and blood vessel systems are important in many life processes and in the pathogenesis of many cardiovascular diseases.Mod
【机 构】
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Inst.of Natural Sci.,Shanghai Jiao Tong Univ.
论文部分内容阅读
The interaction between blood flow and blood vessel systems are important in many life processes and in the pathogenesis of many cardiovascular diseases.Modeling studies of these life processes,such as the blood flow regulation,the blood vessel adaptation,and the blood wave propagation,have provided deep understandings of relevant experimental observations.In this mini-symposium,we will report our recent works on the modeling these important life processes and the application of these models in explaining experimental phenomena.The adaptation of blood vessels in response to the stimulus induced by the wall shear stress of the blood flow is applied successfully in predicting the vessel pruning in embryo zebra fish.The onedimensional model of blood pulse wave is used in explaining the correlation between pulse phases and diseases,such as the wiry pulse and hypertention.The model of arteriole smooth muscle cells based on Ca2+signaling predicts spontaneous vasomotion and the auto regulation of blood flow in arterioles.This mini-symposium will not only provide a platform for us to present the recent discoveries in modeling and experimental studies of the interaction between blood flow and blood vessel systems,but also provide a platform to discuss the future collaborations towards an integrated and deep understanding on the functional mechanism of the cardiovascular systems and the pathogenesis mechanism of a few important cardiovascular diseases.
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