Superoxide Depression in the Rostral Ventrolateral Medulla Contributes to Centrally Antihypertensive

• 作 者: YangkaiWang;WeizhongWang;
• 机 构: Department of Physiology,Second Military Medical University,Shanghai 200433
• 出 处: 中国生理学会第24届全国会员代表大会暨生理学学术大会
• 发表日期: 2004年期

　　BACKGROUND AND PURPOSE:It has been demonstrated that centrally antihypertensive action of moxonidine is resulted from activation of Imidazoline-1 receptor (I1R) in the rostral ventrolateral medulla (RVLM).Increased superoxide in the RVLM contributes to high level of blood pressure and sympathetic outflow in hypertension.