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Objective: This study aims to discuss the treatment strategiesand curative effect of removing the compression symptoms from the lymphoma of patients with superior vena cava syndrome(SVCS).Methods: A total of 31 lymphoma cases with SVCS were analyzed retrospectively.All patients were treated in our department from January 2009 to August 2012.All patients were pathologically diagnosed with lymphoma along with SVCS by imaging examination and/or clinical manifestation.The pre-treatment included prednisone (30 to 60 mg/day) or dexamethasone (5 to 15 mg/day), vindesine (2 to 4 mg/day),and other support treatments.