Design,synthesis,and Antitumor Activity of novel quinoline and 1,2-dihydroquinoline derivatives conn

• 作 者: QidongTang;HuafangLin;ChenXu;PengchengLi;PingGong;
• 机 构: 37＃,Shenyang Pharmaceutical University,103 Wenhua Road,Shenhe District,Shenyang 110016
• 出 处: 全国药物化学学术会议暨第四届中英药物化学学术会议
• 发表日期: 2013年期

　　A series of novel quinoline and 1,2-dihydroquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized,and evaluated for their c-Met kinase inhibitory activity and antiproliferative activity against 5 cancer cell lines(HT-29,H460,MKN-45,A549,and U87MG)were evaluated in vitro.