Adrenergic signaling mediates pancreatic hyperalgesia through activation of purinergic receptors in

• 作 者: 徐广银;朱宏岩;周友浪;周媛;袁波;张春华;胡淑芬;张弘弘;
• 机 构: 苏州大学神经科学研究所,江苏省重大神经精神疾病诊疗技术研究重点实验室,苏州市疼痛研究与临床治疗重点实验室,苏州,215123
• 出 处: 中国生理学会第24届全国会员代表大会暨生理学学术大会
• 发表日期: 2014年期

　　Objective: The mechanism of pain in chronic pancreatitis(CP)is poorly understood and its treatment remains difficult,in large part due to our lack of knowledge about the neurobiological mechanisms in nociception.The aim of this study was designed to investigate roles of norepinephrine(NE)and P2X receptor signaling pathway in the pathogenesis of pancreatic pain in a rat model of CP.