Single-step bioproduction of the simvastatin precursor monacolin J in an industrial strain of Asperg

• 作 者: Xuenian Huang Bo Liang Yajing Liang Yong Yang Yun Teng Linghui Zhang Xuefeng Lu
• 机 构: Key Laboratory of Biofuels,Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy
• 出 处: 中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
• 发表日期: 2018年10期
• 关键词: Monacolin J Simvastatin lovastatin hydrolase Aspergillus terreus directed evolut

　　Monacolin J is a key precursor for the synthesis of simvastatin(Zocor),an important drug for treating hypercholesterolemia.Industrially,monacolin J is manufactured through alkaline hydrolysis of lovastatin,a fungal polyketide produced by Aspergillus terreus.Multistep chemical processes for the conversion of lovastatin to simvastatin are laborious,cost expensive and environmentally unfriendly.