论文部分内容阅读
Coronavirus spike (S) glycoproteins mediate receptor binding,membrane fusion,and virus entry and determine host range.Murine betacoronavirus (β-CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its receptor,whereas β-CoVs SARS-CoV in group B and MERS-CoV in group C,respectively,and several α-CoVs use the downstream C-domain in their S proteins to recognize their receptor proteins.