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In vitro tests form an essential part of the assessment of genotoxicity and provide information on three major genetic endpoints, mutagenicity, clastogenicity and aneugenicity.However, evaluation of several databases demonstrated that an increase in the number of tests performed results in an increase of the number of unexpected positives while the number of unexpected negatives decreases (Kirkland et al., 2005).Therefore, a 2 test battery was suggested by Kirkland et al (2011), consisting of the bacterial reverse mutation test (Ames test) and the mammalian cell in vitro micronucleus test.This two test battery has a comparable sensitivity than a three test battery and allowed the detection of all relevant genotoxic carcinogens and in vivo genotoxicants for which data existed in the databases used (over 950 compounds).