SK Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：shadowhigher

【摘要】

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【作者】

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Tingting Yang Hai-Liang Zhang Qingnan Liang Yingtang Shi Yan-Ai Mei Paula Q.Barrett Changlong Hu

【机构】

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Department of Physiology and Biophysics,School of Life Sciences,Fudan University,Shanghai,China

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

【关键词】

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SK channels aldosterone secretion zona glomerulosa cells Apamin

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　　Aldosterone,produced by zona glomerulosa(ZG)cells of the adrenal cortex,plays a key role in maintaining water and electrolyte balance.Autonomous overproduction of aldosterone from ZG cells causes Primary hyperaldosteronism(PA).Recent clinical studies have highlighted the pathologic role of the KCNJ5 potassium channel in PA.

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SK Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells

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