【摘 要】
：
To investigated the roles of cysteinyl leukotriene receptor 1 (CysLT1 R) in Aβ1-42-induced neurotoxicity in vitro or in vivo.In vitro exposure of mouse pri
【机 构】
：
Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China
【出 处】
：
第十六届全国神经精神药理学学术会议
论文部分内容阅读
To investigated the roles of cysteinyl leukotriene receptor 1 (CysLT1 R) in Aβ1-42-induced neurotoxicity in vitro or in vivo.In vitro exposure of mouse primary neurons to Aβ1-42 caused gradual increases in CysLT1R expression.In vivo bilateral intrahippocampal injection of Aβ1-42 also elicited time-dependent increases of CysLT1 R expression in either hippocampus or cortex of mice.CysLT1R antagonist pranlukast not only reversed Aβ1-42-induced upregulation of CysLT1R, but also suppressed Aβ1-42-triggered neurotoxicity evidenced by increased NFκB p65, activated caspase-3, decreased Bcl-2, reduced cellular viability and impaired memory.Furthermore, Chronic treatment with pranlukast produced similar beneficial effects on memory behavior and hippocampal LTP to memantine or donepezil in intrahippocampal Aβ1-42-injected mice.Our data indicate that CysLT1R is involved in Aβ1-42-induced neurotoxicity and blockade of CysLT1 R, such as application of CysLT1 R antagonist, could be a novel and promising strategy for treatment of AD.
其他文献
目的 探讨低剂量阿魏酸和胡椒碱阈下剂量联用对小鼠抑郁样行为的改变及其可能的机制。方法 根据单用阿魏酸与单用胡椒碱急性治疗抑郁样小鼠所得ID50值选取低剂量阿魏酸以
American ginseng extract (AGE) has been shown to have a lot of beneficial effects on disorders of central nervous system.In this paper, the neuroprotective
目的 探讨阿魏酸对急性应激模型小鼠抑郁样行为的影响及可能的作用机制.方法 通过强迫游泳测试和悬尾测试造急性抑郁小鼠模型，测试前急性给药给予不同剂量的阿魏酸，测试前0
目的 应用大鼠慢性应激模型探讨5-HT1A受体激动和5-HT重摄取抑制双靶标抗抑郁剂YL-0919抗抑郁作用.方法 连续5周交替采用多种不可预知的刺激方式,以建立大鼠的慢性不可预
目的 研究小补心汤总黄酮(XBXT-2)调控糖原合成酶激酶3β (GSK3β)及其相关信号通路的机制。方法 ①建立小鼠慢性不可预知性应激模型,采用开场实验、蔗糖饮水实验评价XBX
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
目的 探讨YL-IPA08的抗抑郁作用及可能作用机制。方法 连续5周以每日一次的频率给予大鼠一系列不可预知的应激刺激以建立慢性应激模型,每次刺激前给予AC5216或YL-IPA08,
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
目的 分离制备柴胡多炔化合物并研究其抗抑郁活性.方法 采用传统提取分离方法与高效液相色谱跟踪法,从柴胡中提取分离得到4种多炔类化合物(RB1～RB4),通过NMR(1H-NMR,13C-N
产前感染和精神分裂症发病风险增高密切相关。因此,孕期注射病毒抗原poly(I∶C)导致免疫应答被认可为制作子代精神分裂症神经发育障碍模型的成熟途径。这种模型的成年后