Active site loop conformation regulates promiscuous activity in a thermostable lactonase towards deg

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：yangjian1235

【摘要】

：

Enzyme promiscuity can function as a starting point in divergent evolution for generatinga specific enzyme in the presence of selective stress.A better understanding of catalyticpromiscuity can improv

【作者】

：

Yan Feng Yu Zhang Jiao An Guangyu Yang

【机构】

：

State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University

【出处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

promiscuous organophosphate

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

DNA损伤修复因子(ARAP1)参与调控雄激素受体AR介导的基因转录及其表观遗传学机制

雄激素受体(Androgen Receptor,AR)是核受体超家族成员,以配体依赖方式介导基因转录,并招募一系列辅调节因子调控其转录,发挥其生物学功能.AR及其辅调节因子分别在前列腺癌中扮演着重要角色.

会议

雄激素受体(AR)转录调控ARAP1组蛋白修饰前列腺癌

Expression, purification and activity determination of protein kinase D1 in baculovirus expression s

Protein kinase D (PKD) is a novel family of serine/threonine kinases and diacylglycerol(DAG) receptors and has been documented in a variety of cellular processes.Threeisoforms of PKD have been identif

会议

protein kinase D1 insect cell baculovirus expression system expression purificat

Metabolism and distribution of newly anti-inflammatory HMGB1 A Box fused with C-terminal acidic tail

Recombinant derived proteins are becoming increasingly important as therapeutic agents.HMGB1, composed of the A box, B box and C tail domains, is a critical proinflammatory cytokineinvolved in diverse

会议

HMGB1 Fusion protein Inflammation 125I-radiolabeled Metabolism and distribution

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.In addition toits known receptor-mediated biological activities,MIF possesses a catalytic site of unknownfunction between sub

会议

MIF strcuture mechanism

Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Ass

Background/Aims:Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S 1P.receptor (S1PR) axis is involved in multiple biological processes,including liver fibrosis.

会议

angiopoietin 1vascular cell adhesion molecule-1von Willebrand factorhepatic s

Overexpression of Wnt5a inhibits the telogen-to-anagen transition of hair follicles in mice

The canonical Wnt/β-catenin pathway plays an important role in hair cycle induction.Wnt5a is a non-canonical Wnt family member that generally antagonizes canonical Wnt signaling in other systems.

会议

Wnt5aHair growthWnt signaling pathwayHair cycle

Suppression of cell growth and migration by blocking hedgehog signaling pathway in gastric cancer ce

Background Previous studies suggest Hedgehog signaling is essential for gastric cancer,but the precise function of Hedgehog signaling in gastric cancer is still unclear.The aim of this study is to cla

会议

Hedgehog signaling pathwaygastric cancerGli1cDNA microarray analysis

Screening of chemoeffectors for Chemoreceptor Tsr to disclose the possible molecular mechanism of re

Chemotaxis is a phenomenon that motile bacteria move directionally alone chemicalgradients in the environment.This ability depends on the chemoreceptors which can deteetminute concentration changes in

会议

chemoreceptor Tsr molecular mechanism

The Protecting Effects of Melatonin on the Hemoglobin Rereleased from the Hydrogen Peroxide (H2O2) D

This study is to observe the protecting effects of melatonin on the hemoglobin re-releasedfrom hydrogen peroxide (H2O2) damaged red blood cells (RBCs).Firstly, RBCs weretreated with 0.25％, 0.5％, 1％, 2

会议

Hydrogen peroxide Melatonin agarose-starch mixed gel electrophoresis Oxidative d

Rational molecular design: driving the rapid evolution of enzymes

Directed molecular evolution of enzymes in vitro is a crucial strategy for understanding thenature enzyme evolution and creating the novel biocatalysts which could meet the requirementsin industrial p

会议

lipase stability active site local rigidity

Active site loop conformation regulates promiscuous activity in a thermostable lactonase towards deg

其他学术论文