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The Rehabilitation & Exercise Oncology Program (REOP) has established the infrastructure and operational resources for translation of significant research on the benefits of exercise for patients with cancer diagnosis into Hospital-based clinical practice.This Model of Care incorporates screening for functional disability and exercise prescription as a primary intervention during and post treatment to maintain and improve performance status.The principle objective is to reduce the number of crises related to the loss of functionally independence and improve quality of life for both patients and their caregivers.Patients are screened at source in oncology clinics, chemotherapy, and radiotherapy by a team of specialized physiotherapists and exercise physiologists assigned to different tumour sites.Standardized functional tests serve to determine performance status and provide a baseline for individualized active lifestyle counselling and exercise prescription.Within the context of REOP a study was conducted to determine whether physiotherapy exercise prescription changes fatigue and low activity levels in young adults undergoing aggressive treatment for cancer.Ninety-seven patients,aged 18 to 45 years, with brain, gastrointestinal, breast, sarcoma, and testicular cancers were consecutively recruited and screened for risks related to exercise.Metabolic equivalent hours of physical activity (MET-hours/week) and the Brief Fatigue Inventory (BFI), were documented at baseline (T 1) and following an average of 6 months of treatment (T2).Paired t-tests were used to compare activity levels and fatigue at T1 and T2.Compliance was documented and independent t-tests used to compare exercisers and non-exercisers.Compliance with exercise prescription was 71%and subjects increased their activity levels from 8.2 to 18.6 MET-hours/week (p<0.01) with no adverse effects.BFI severity and impact scores remained stable (p>0.05).Exercisers had significantly higher activity levels and lower fatigue than non-exercisers at T2 (p<0.05).Non-exercisers deteriorated functionally to levels of bedrest.This translational research Program allows for study of specific rehabilitation and exercise interventions for both solid tumours and hematological malignancies.Unique studies are in process of being developed in bone disease and bone metastasis, radiation fibrosis, lymphedema, peripheral neuropathy, chronic fatigue, and neurocognitive dysfunction.Partnerships with university based Rehabilitation and Exercise Science Programs ensure the establishment of high quality research and student mentorship in this important field of specialization.